Inflammation, Atherosclerosis and Coronary Artery Disease
نویسندگان
چکیده
In 1856, Rudolf Virchow proposed that the atherosclerosis was caused when plasma components (including lipids) elicited an inflammatory response in the arterial wall. Current research also points that inflammation plays a central role in genesis of atherosclerosis and its complications. In early atherosclerotic lesions, immune cells dominate and their effector cells leads to progression of atherosclerosis. The inflammatory process has been implicated in the vulnerability of the plaque leading to plaque rupture, leading to Acute Coronary Syndrome. Understanding the role of inflammation in causation of the atherosclerosis and coronary artery disease will lead to new vistas in prediction, prevention and treatment of cardiovascular diseases.
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